A4665
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A4665
Sigma
Alamethicin from Trichoderma viride
≥90% (HPLC)
| Synonym: | Antibiotic U-22324 |
| CAS Number: | 27061-78-5 |
| Beilstein Registry Number: | 5213858 |
| MDL number: | MFCD00151517 |
| PubChem Substance ID: | 24890893 |
Description
| Antibody Adsorbant | Ac-2-MeAla-L-Pro-2-MeAla-L-Ala-2-MeAla-L-Ala-L-Glu(NH2)-2-MeAla-L-Val-2-MeAla-Gly-L-Leu-2-MeAla-L-Pro-L-Val-2-MeAla-2-MeAla-L-Glu-L-Glu(NH2)-phenylalaninol |
| Biochem/physiol Actions | Monovalent cation ionophore; can mimic nerve action potential across artificial membranes. |
| Quality | A mixture of alamethicin homologs |
Properties
| assay | ≥90% (HPLC) |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| RIDADR | UN3462 6.1/PG 3 |
| WGK Germany | 3 |
References
| reference | Cosette, P., et al., The ion-channel activity of longibrachins LGA I and LGB II: effects of Pro-2/Ala and Gln-18/Glu substitutions on the alamethicin voltage-gated membrane channels. Biochim. Biophys. Acta 1461, 113-122, (1999) Abstract |
| Duclohier, H., et al., C-terminally shortened alamethicin on templates: influence of the linkers on conductances. Biochim. Biophys. Acta 1420, 14-22, (1999) Abstract | |
| Tieleman, D.P., et al., Surface binding of alamethicin stabilizes its helical structure: molecular dynamics simulations. Biophys. J. 76, 3186-3191, (1999) Abstract |
